Behcet’s syndrome is a chronic inflammatory disease and often have a relapse, which can cause recurrent pain in the wound in the mouth, blisters on the skin, sores on the genitals and swollen joints.
Eyes, blood vessels, nervous system and digestive tract can also become inflamed.This syndrome is 2 times more often on men. Usually arise in the 20s, but occasionally occur in childhood. The disease is rarely found in the U.S.. People from Mediterranean countries, Japan, Korea and the regions along the silk route through China, has the highest risk of occurrence of this syndrome.
The cause is unknown, but viral and autoimmune diseases thought to play a role in this disease.
Almost all patients experienced mouth sores are painful and repetitive (similar to chancre sores), which is usually the initial symptom. Sores on the penis, scrotum and vulva bag tends to pain, while the wounds in the vagina do not cause pain.
Other symptoms appear several days or even several years later. Recurrent inflammation of the eye (iridosiklitis relapse) causes pain in the eye, sensitive to light and foggy vision. Some other eye disorders can occur, such as uveitis, which can cause blindness if not treated.
Blisters on the skin and pus pimples occurs in approximately 80% of patients. Minor injuries, even though the needle puncture, can cause this area to swell and become inflamed. Approximately 50% of patients experiencing non-progressive arthritis is relatively mild in the knees and other large joints.
Inflammation of blood vessels (vasculitis) throughout the body can cause:
– Formation of blood clots
– Aneurysm (bulging blood vessel walls are weak)
– Kidney damage.
If the digestive tract, the symptoms can range from mild discomfort to severe abdominal cramps and diarrhea. Symptoms or symptom-free period of this syndrome can last for several weeks, years or even decades. Complications are most likely to occur is paralysis. Sometimes the damage of the nervous system, gastrointestinal tract or blood vessels can be fatal.
Diagnosis based on physical examination because there is no laboratory test that can detect Behcet’s syndrome. Symptoms are similar to other diseases, such as Reiter’s syndrome, Stevens-Johnson syndrome, systemic lupus erythematosus, Crohn’s disease and ulcerative colitis.
Corticosteroid eye drops or ointment may help cure an inflamed eye and skin injuries. Eye inflammation or severe nervous system may require prednisone or other corticosteroids. Cyclosporine (immunosuppressant drugs) is given if eye problems are very severe or if the prednisone is not able to control the symptoms.