Cushing’s syndrome- It is a hormone disorder caused by taking glucocorticoid drugs and by tumor thatproduce cortisol or adrenocorticotropic hormones (ACTH) and it is also found in domestic animals.Cushing’s disease is refer as tumor of pituitary gland that produce large amount of ACTH.
Symptom – Some symptoms areobesity , weight gain ,Hyper hidrosis(excess sweating), baldness, Telangiestasia( widening of artery ) , dermatophyte and malassez infection , polyuria( excessive urination ) , hirsutism ,hypertension .
a)Exogenous-excess hormone is coming from out side i.e glucocorticoid Drugs taking for otherdisease . too much taking of prednisone and prednisolone for treatment of other disease like asthamaor rheumatoid arthritis .
b) endogenous -excess hormone due to internalorgan disorder eg. Pitutary gland tumor ,adrenalgland tumor ,lung cancer or cancer else where that produce cortisol .
Pseudo – cushing’s syndrome – Estrogen can cause increase of cortisol- binding globulin result in high cotisol level .
Symptoms- upper body obesity , round or moon face ,excessive growth of hair , abnormal menses , collection of fat between the shoulders , high bp , increase thirst and urination .
Diagnosis – dexamethasone suppression test (administration of dexamethasone and frequent check of cortisol and ACTH level) , salivary cortisol level ,
CT scanning of the adrenal gland and MRI of the pituitary gland are performed to detect the presence of any adrenal of pituitary adenomas .
Treatment – An ACTH-secreting corticotrophic pituitary adenoma should be removed after diagnosis. And steroid replacement , Regardless of the adenoma’s location.Drugs that inhibit cortisol synthesis (e.g. ketoconazole, metyrapone) .