Ted Lyons: 260 wins
The Chicago White Sox’s all-time wins leader is Hall of Famer Ted Lyons. From 1923 to 1946, Lyons played his entire 21-year career in a White Sox uniform, recording double-digit wins in all but four seasons. He led the American League in wins twice, first in 1925 with 21 and again in 1927 with 22. As his career progressed, Lyons demonstrated increasingly great control. For three of his last four full seasons, he had the lowest walk rate in the AL.
Red Faber: 254 wins
A Hall of Fame righty who spent his entire 20-year career with the team, Red Faber ranks second on the Chicago White Sox’s all-time wins list. An owner of four 20-win seasons, Faber threw more than 4,000 innings with a 3.15 ERA. He won three games in the 1917 World Series including the decisive game six. In 1926, Faber became the first pitcher to win 200 games in a White Sox uniform.
Ed Walsh: 195 wins
Hall of Famer Ed Walsh ranks third among the Chicago White Sox’s all-time wins leaders. From 1904 to 1916, Walsh was consistently one of the most effective pitchers in baseball. As a member of the White Sox, his ERA never made it as high as 3.00 and he still holds the Major League record for lowest career ERA at 1.82. The spitballer won two games in the 1906 World Series to help the White Sox win their first championship. In 1908, Walsh became the last pitcher to win 40 games in a season.
Billy Pierce: 186 wins
One of the best pitchers of the 1950s, Billy Pierce ranks fourth among the Chicago White Sox all-time wins leaders. The White Sox acquired Pierce from the Tigers for Aaron Robinson in what turned out to be a remarkably one-sided deal. In 13 seasons with the White Sox from 1949 to 1961, Pierce earned seven All-Star appearances with a 3.19 ERA in 2,931 innings. He tossed 183 complete games in 390 starts for the White Sox.
Wilbur Wood: 163 wins
Three-time All-Star Wilbur Wood ranks fifth on the Chicago White Sox’s all-time wins list. After a few partial seasons in Boston and Pittsburgh, Wood pitched in Chicago for 12 years from 1967 to 1978 as a rare bright spot on the team in that era. Beginning in 1971, he put together a stretch of four consecutive 20-win seasons, leading the AL twice in that span. He had an ERA of 3.18 during his tenure, including two seasons of a sub-2.00 ERA.