Cholestasis Disease

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Cholestasis is the reduction or cessation of bile flow.
Cholestasis is a disorder of the formation, secretion and drainage of bile from hepatocytes, bile duct intracellular, extracellular and extra-hepatal
Cholestasis is a disease caused by abnormalities in the liver or biliary system (bile), causing the flow of all materials should be disposed of by the liver and biliary tract to be disturbed
The cause of cholestasis is divided into two groups, namely:
1. Derived from the heart
a) Hepatitis
b) alcoholic liver disease
c) primary biliary cirrhosis
d) As a result of drugs
e) Due to changes in hormones during pregnancy (cholestasis of pregnancy).
2. Coming from outside the heart
a) stone in the bile duct
b) Narrowing of the bile duct
c) bile duct cancer
d) Pancreatic cancer
e) Inflammation of the pancreas.
Signs and symptoms of cholestasis include the following:
1. Yellowish skin due to high levels of bilirubin (bile pigment)
2. Itching in the skin
3. Dark urine
4. Feces pale as putty
5. Enlarged abdomen
Jaundice and dark urine is due to the excessive amount of bilirubin in the skin and urine. Feces sometimes appear pale due to lack of bilirubin in the intestine. Feces may also contain too much fat because there is no fluid in the intestine of bile to help digest fat. If cholestasis persists, a deficiency of calcium and vitamin D will cause bone loss with symptoms of pain in the bones and the risk of fractures. Another consequence of the interference with the absorption of the materials needed for blood clotting, so patients are very susceptible to bleeding.


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