Coenzyme Q10 (CoQ 10) or ubiquinone is essentially a vitamin or vitamin-like substance. Vitamins are defined as organic compounds essential in minute amounts for normal body function acting as coenzymes or precursors to coenzymes. They are present naturally in foods and sometimes are also synthesized in the body. CoQ10 likewise is found in small amounts in a wide variety of foods and is synthesized in all tissues. Coenzyme Q10 is the coenzyme for at least three mitochondrial enzymes (complexes I, II and III) as well as enzymes in other parts of the cell.
Use of Coenzyme Q10 in treating Heart Disease:
CoQ10 is known to be highly concentrated in heart muscle cells due to the high energy requirements of this cell type. Congestive heart failure has been strongly correlated with significantly low blood and tissue levels of CoQ10 . The severity of heart failure correlates with the severity of CoQ10 deficiency. This deficiency of CoQ10 appears to be a major treatable factor in the progression of heart failure. On administration of Coenzyme Q10, Heart function, showed a gradual and sustained improvement with a gradual and sustained improvement in patients’ symptoms of fatigue, dyspnea, chest pain, and palpitations.
The most recent work in heart failure examined the effect of CoQ10 on diastolic dysfunction, one of the earliest identifiable signs of myocardial failure that is often found in mitral valve prolapse, hypertensive heart disease and certain fatigue syndromes. Diastolic function has a larger cellular energy requirement than the systolic contraction and, therefore, the process of diastolic relaxation is more highly energy dependent and thus more highly dependent on CoQ10.In simpler terms, it takes more energy to fill the heart than to empty it.
It is important to note that in all of the above clinical trials, CoQ10 was used in addition to traditional medical treatments, not to their exclusion. Hence it can only be used as adjuvant and not sole treatment for Heart Diseases.